Saturday, July 9, 2011

Reprogram Brain and Skin cells into Heart cells

A group of researchers at the Perelman School of Medicine of Pennsylvania University for the first time have succeeded in transforming two different cell-types (astrocyte, a brain cell and a fibroblast, a skin cell) into a heart cell using mRNAs (messenger RNAs are the molecules which contain the blueprints for protein). It is a breakthrough in medicine as it is going to pave the way for cell-based therapy for cardiovascular diseases.

Researchers have used a method called Transcriptome Induced Phenotype Remodeling which is similar to prior nucleus transfer from one cell to another cell which then directs the cell to change the phenotype based on the RNAs that are made. The advantage of this method is that it does not need an intermediate step. This research might make it possible now to repair the injured hearts by replacing lost tissue.  

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